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Ceftriaxone 500mg Salt Information :
Side Effects of Ceftriaxone 500mg:
Superinfection; anaphylaxis; diarrhoea; local reactions; blood dyscrasias; rash, fever, pruritus; elevated transaminases and alkaline phosphatase; leucopenia, neutropenia. Potentially Fatal: Pseudomembranous colitis; nephrotoxicity.
Drug Interactions of Ceftriaxone 500mg:
Disulfiram-like reaction with alcohol. Potentially Fatal: Nephrotoxicity with aminoglycosides and furosemide.
Contraindications of Ceftriaxone 500mg:
Hypersensitivity to cephalosporins; hyperbilirubinaemic neonates. Do not use calcium or calcium-containing solutions or products with or within 48 hr of ceftriaxone administration due to risk of calcium-ceftriaxone precipitate formation.
Mechanism of Action of Ceftriaxone 500mg:
Ceftriaxone binds to one or more of the penicillin-binding proteins (PBPs) which inhibits the final transpeptidation step of peptidoglycan synthesis in bacterial cell wall, thus inhibiting biosynthesis and arresting cell wall assembly resulting in bacterial cell death. Absorption: Peak plasma concentrations after 2 hr (IM). Distribution: Distributed widely into body tissues and fluids; CSF (therapeutic concentrations). Crosses the placenta and enters breast milk; bile (high concentrations). Protein-binding: 85-95%. Excretion: Via the urine (40-65% as unchanged); via the bile to the faeces (remainder as unchanged and microbiologically inactive compounds); 6-9 hr (elimination half-life).
Special Precautions for Ceftriaxone 500mg:
History of penicillin allergy; severe renal impairment; pregnancy and lactation; superinfection.
|Composition of Product||Ceftriaxone 500 mg|
|Pack Size||500 mg|
|Pack Type||Vial with SWFI|
|Storage||store in a cool place|