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Cefpodoxime 200mg + Ofloxacin 200mg Salt Information :

Uses of Cefpodoxime 200mg + Ofloxacin 200mg:
Cefpodoxime and ofloxacin combination is used in the treatment of various bacterial infections like pneumonia, bronchitis, urinary tract infections and sinusitis.

Side Effects of Cefpodoxime 200mg + Ofloxacin 200mg:
Anaphylactic shock; purpuric nephritis, skin rash, pruritus; diarrhoea, nausea, abdominal pain, vomiting. Potentially Fatal: Pseudomembranous colitis; nephrotoxicity.

Drug Interactions of Cefpodoxime 200mg + Ofloxacin 200mg:
Antacids or H2-blockers may decrease the absorption of cefpodoxime. Probenecid inhibits renal excretion. Potentially Fatal: Monitor renal function during admin. Additive nephrotoxic effects with furosemide.

Contraindications of Cefpodoxime 200mg + Ofloxacin 200mg:
Hypersensitivity.

Mechanism of Action of Cefpodoxime 200mg + Ofloxacin 200mg:
Cefpodoxime binds to one or more of the penicillin-binding proteins (PBPs) which inhibits the final transpeptidation step of peptidoglycan synthesis in bacterial cell wall, thus inhibiting biosynthesis and arresting cell wall assembly resulting in bacterial cell death. Absorption: Decreased absorption in conditions of low gastric acidity. Bioavailability: about 50%. Distribution: Respiratory and GU tract (therapeutic concentrations); enters breast milk (low concentrations). Protein-binding: 20-30%. Metabolism: De-esterified to cefpodoxime in the intestinal lumen. Excretion: Via the urine (as unchanged); removed by dialysis; 2-3 hr (elimination half-life); prolonged in renal impariment.

Special Precautions for Cefpodoxime 200mg + Ofloxacin 200mg:
History of allergy to penicillin; severe renal impairment; pregnancy and lactation.