|Composition of Product||Rabeprazole 20 mg+ Domperidone 10 mg|
|Therapeutic Classification||PPI (Proton pump inhibitors)|
|Storage||store in a cool, dry place and avoid direct sunlight|
Each tablet contains:
Rabeprazole is a proton pump inhibitor sometimes identified as an ulcer healing drug. This is also very beneficial for inhibition of secretion from stomach as well as to treat various acid related gastrointestinal conditions. It heals stomach and intestinal ulcers and also manages GERD.
Domperidone is a dopamine antagonist with anti-emetic properties. Antiemetic activity is due to the blockade of dopamine receptors in the chemoreceptor trigger zone (CTZ). It increases lower esophageal pressure, improve duodenal motility, and accelerate gastric emptying.
GERD, heartburn, hyperacidity, reflux oesophagitis, regurgitation, flatulence, gastric and peptic ulcer.
Dosage & Administration
ZOLPPI-D should be taken as directed by the physician.
ZOLPPI-D is contraindicated in patients with known hypersensitivity to rabeprazole, substituted benzimidazole, domperidone or to any component of the formulation. It should not be used whenever stimulation of gastric motility is to be avoided or could be harmful, e.g. in the presence of gastro-intestinal hemorrhage, obstruction or perforation. It is also contra-indicated in patients with a prolactin-releasing pituitary tumor (prolactinoma).
ZOLPPI-D should be used with caution in patients with renal impairment or in those at risk of fluid retention. In patients with severe renal the elimination half-life of domperidone is increased.
Since domperidone is highly metabolized in the liver , ZOLPPI-D should be used with caution in patients with hepatic impairment
Diarrhoea, dizziness, headache, nausea, vomiting, rash, tiredness.
Pregnancy & Lactaton
ZOLPPI-D should be used during pregnancy only if clearly needed. Since many drugs are excreted in milk, caution should be exercised when this drug is administered to a nursing mother.
ZOLPPI-D tablets are available in a 10X10’s Alu Alu packing.
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