|Composition of Product||Rabeprazole 20 mg + Itopride 150mg|
|Therapeutic Classification||PPI (Proton pump inhibitors)|
|Storage||store in a cool, dry place and avoid direct sunlight|
Uses of Rabeprazole 20mg + Itopride 150mg:
Rabeprazole and Itopride combination is used in the treatment of irritable bowel syndrome. This medicine improves gastric motility , gastro-duodenal coordination and thus helps in smooth emptying of stomach .
Side Effects of Rabeprazole 20mg + Itopride 150mg:
Headache, diarrhoea, dizziness, rash. Potentially Fatal: Anaphylaxis, agranulocytosis.
Drug Interactions of Rabeprazole 20mg + Itopride 150mg:
Rabeprazole increase elimination T1/2 of digoxin, decreases effects with aminoglutethimide, carbamazepine, phenytoin and rifampin and reduces absorption of ketoconazole and itraconazole. Anticholinergic agents reduces the action of itopride.
Contraindications of Rabeprazole 20mg + Itopride 150mg:
Mechanism of Action of Rabeprazole 20mg + Itopride 150mg:
Rabeprazole is a PPI that suppresses gastric acid secretion by inhibiting the gastric H+/K+ ATPase at the secretory surface of the gastric parietal cell. Itopride increases acetylcholine (ACh) concentrations by inhibiting dopamine D2 receptors and acetylcholinesterase. Higher ACh increases GI peristalsis, increases the lower oesophageal sphincter pressure, stimulates gastric motility, accelerates gastric emptying, and improves gastro-duodenal coordination.
Special Precautions for Rabeprazole 20mg + Itopride 150mg:
Itopride should be used with caution because it enhances the action of acetylcholine Rabeprazole should be used with caution in patients with severe hepatic impairment. Pregnancy.