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Montelukast 5mg + Levocetirizine 2.5mg Salt Information :
Side Effects of Montelukast 4mg + Levocetirizine 2.5mg:
Dizziness, fatigue, fever; rash; abdominal pain, dyspepsia, dental pain, gastroenteritis; increased AST; weakness; cough, nasal congestion. Aggression, agitation, angioedema, arthralgia, bleeding tendency, bruising, cholestasis, diarrhoea, dream abnormalities, drowsiness, oedema, eosinophilia, hallucinations, hepatic eosinophilic infiltration (rare), hepatitis, hypersensitivity, hypoaesthesia, insomnia, irritability, muscle cramps, myalgia, nausea, palpitation, pancreatitis, paraesthesia, pruritus, restlessness, seizure, urticaria, vasculitis, vomiting. Potentially Fatal: Anaphylaxis, Churg-Strauss syndrome.
Drug Interactions of Montelukast 5mg + Levocetirizine 2.5mg:
Metabolism may be increased with rifampicin, phenobarbital, phenytoin. Peripheral oedema may occur with prednisone.
Mechanism of Action of Montelukast 5mg + Levocetirizine 2.5mg:
Montelukast is a selective leukotriene receptor antagonist that blocks the effects of cysteinyl leukotrienes in the airways. Absorption: Rapidly absorbed from the GI tract (oral). Peak plasma concentrations in 2-4 hr. Mean oral bioavailability: 64%. Distribution: Protein-binding: >99%. Metabolism: Extensively hepatic by CYP3A4, CYP2A6 and CYP2C9 isoenzymes. Excretion: Principally via faeces; elimination half-life prolonged in mild to moderate hepatic impairment.
Special Precautions for Montelukast 5mg + Levocetirizine 2.5mg:
Not for the relief of acute bronchospasm. Not to be used as monotherapy for the prevention of exercise-induced bronchospasm. Patients in whom asthma is precipitated by aspirin or other NSAIDs should continue to avoid aspirin and NSAIDs. Do not abruptly substitute for oral or inhaled corticosteroids. Be alert for any signs of Churg-Strauss syndrome. Pregnancy and lactation. Children <6 mth.
|Composition of Product||Montelukast 5 mg+ Levocetirizine 2.5 mg|
|Therapeutic Classification||Anti-Histamine /Anticold|
|Storage||store in a cool, dry place and avoid direct sunlight|