|Composition of Product||Methylcobalamine 750mcg +Pregabalin 75mg|
|Storage||store in a cool, dry place and avoid direct sunlight|
Pregabalin 75mg + Methylcobalamin 750mcg Salt Information :
Uses of Pregabalin 75mg + Methylcobalamin 750mcg:
Pregabalin and Methylcobalamin combination is used various nerve pain conditions like fibromyalgia or diabetic neuropathy .
Side Effects of Pregabalin 75mg + Methylcobalamin 750mcg:
Dizziness, drowsiness, visual disturbance (including blurred vision, diplopia), ataxia, dysarthria, tremor, lethargy, memory impairment, euphoria, wt gain, constipation, dry mouth, peripheral edema, depression, confusion, agitation, hallucinations, myoclonus, hypoaesthesia, hyperaesthesia, tachycardia, excessive salivation, sweating, flushing, rash, muscle cramp, myalgia, arthralgia, urinary incontinence, dysuria, thrombocytopenia, neutropenia, 1st ° heart block, hypotension, hypertension, pancreatitis, dysphagia, oliguria, rhabdomyolysis.
Drug Interactions of Pregabalin 75mg + Methylcobalamin 750mcg:
Concurrent use with oxycodone, lorazepam and ethanol may increase the CNS effects.
Contraindications of Pregabalin 75mg + Methylcobalamin 750mcg:
Hypersensitivity. Pregnancy, lactation. Driving or working with machines, or do other dangerous activities.
Mechanism of Action of Pregabalin 75mg + Methylcobalamin 750mcg:
Pregabalin is an analog of the neurotransmitter GABA. It binds potently to the alpha2-delta subunit resulting in modulation of Ca channels and reduction in the release of several neurotransmitters, including glutamate, norepinephrine, serotonin, dopamine, and substance P. Absorption: Rapidly absorbed after oral doses. Peak plasma concentrations are achieved within 1.5 hr. Distribution: Not bound to plasma proteins. Metabolism: Negligible metabolism. Excretion: About 98% excreted unchanged in urine. Elimination half life: about 6.3 hr.
Special Precautions for Pregabalin 75mg + Methylcobalamin 750mcg:
Discontinue treatment if patients develop severe angioedema. Withdraw treatment gradually over at least 1 wk. May cause peripheral oedema. Regular vision check is recommended. May decrease platelet count and prolong PR interval.